Autor Tema: Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via...  (Leído 389 veces)

0 Usuarios y 1 Visitante están viendo este tema.

Desconectado 9delta

  • Moderador General
  • Erudito de la vaporización
  • ******
  • Join Date: Feb 2011
  • Mensajes: 5.092
  • Liked: 51
  • Reputación: +755/-10
  • Vaporizar es salud
Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization

Sonia Hernández-Tiedra, Gemma Fabriàs, David Dávila, Íñigo J. Salanueva, Josefina Casas, L. Ruth Montes, Zuriñe Antón, Elena García-Taboada, María Salazar-Roa, Mar Lorente, Jesper Nylandsted, Jane Armstrong, Israel LópezValero, Christopher S. McKee, Ana Serrano-Puebla, Roberto García-López, José González-Martínez, José L. Abad, Kentaro Hanada, Patricia Boya, Félix Goñi, Manuel Guzmán, Penny Lovat, Marja Jäättelä, Alicia Alonso y Guillermo Velasco


Abstract 
Autophagy is considered primarily a cell survival process, although it can also lead to cell death. However, the factors that dictate the shift between these 2 opposite outcomes remain largely unknown. In this work, we used Δ9-tetrahydrocannabinol (THC, the main active component of marijuana, a compound that triggers autophagy-mediated cancer cell death) and nutrient deprivation (an autophagic stimulus that triggers cytoprotective autophagy) to investigate the precise molecular mechanisms responsible for the activation of cytotoxic autophagy in cancer cells. By using a wide array of experimental approaches we show that THC (but not nutrient deprivation) increases the dihydroceramide:ceramide ratio in the endoplasmic reticulum of glioma cells, and this alteration is directed to autophagosomes and autolysosomes to promote lysosomal membrane permeabilization, cathepsin release and the subsequent activation of apoptotic cell death. These findings pave the way to clarify the regulatory mechanisms that determine the selective activation of autophagy-mediated cancer cell death.


El título del artículo lo traduciría como: "El incremento de dihidroceramidas intercede en la autofagia citotóxica de las células cancerosas a través de la desestabilización del autolisosoma"


Enlace al artículo: You are not allowed to view links. Register or Login

Resumen del estudio en español: You are not allowed to view links. Register or Login


Referencia bibliográfica:
Hernández-Tiedra, S., Fabriàs, G., Dávila, D., Salanueva, Í, Casas, J., Montes, L. R., . . . Velasco, G. (2016). Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization. Autophagy, , 1-17. doi:10.1080/15548627.2016.1213927
(Sorry, but you are not allowed to access the gallery)
(click to show/hide)